F.R. Ehrmann

Six Biophysical Screening Methods Miss a Large Proportion of Crystallographically Discovered Fragment Hits: A Case Study

J. Schiebel, Nedyalka Radeva, S.G. Krimmer et al. · ACS Chemical Biology · 2016 · 125 citations

X-ray Crystallography, Hit Identification, Microscopy +23

High-Throughput Crystallography: Reliable and Efficient Identification of Fragment Hits

J. Schiebel, S.G. Krimmer, Karine Röwer et al. · Structure · 2016 · 92 citations · Full text

X-ray Crystallography, Crystal Structure, Fragment Hits +8

Soaking suggests “alternative facts”: Only co-crystallization discloses major ligand-induced interface rearrangements of a homodimeric tRNA-binding protein indicating a novel mode-of-inhibition

F.R. Ehrmann, Johann Stojko, A. Metz et al. · PLoS ONE · 2017 · 40 citations · Full text

Novel Twisted Dimer, Protein Assembly, Molecular Biology +19

Active Site Mapping of an Aspartic Protease by Multiple Fragment Crystal Structures: Versatile Warheads To Address a Catalytic Dyad

Nedyalka Radeva, J. Schiebel, Xiaojie Wang et al. · Journal of Medicinal Chemistry · 2016 · 18 citations

Experimental Active-Site Mapping by Fragments: Hot Spots Remote from the Catalytic Center of Endothiapepsin

Nedyalka Radeva, S.G. Krimmer, Martin Stieler et al. · Journal of Medicinal Chemistry · 2016 · 16 citations

Protein Assembly, Biomolecular Structure Prediction, Molecular Biology +22