Thiazolopyrimidine Inhibitors of 2‐Methylerythritol 2,4‐Cyclodiphosphate Synthase (IspF) from <i>Mycobacterium tuberculosis</i> and <i>Plasmodium falciparum</i>

Julie G. Geist, Susan Lauw, Victoria Illarionova, +13

ChemMedChem

Nonphosphate Inhibitors of IspE Protein, a Kinase in the Non‐Mevalonate Pathway for Isoprenoid Biosynthesis and a Potential Target for Antimalarial Therapy

Anna K. H. Hirsch, Susan Lauw, Philipp Gersbach, +5

ChemMedChem

Antiparasitic AgentIspe ProteinChemical BiologyKinase IspeMolecular Pharmacology +14

Inhibitors of the kinase IspE: structure–activity relationships and co-crystal structure analysis

Anna K. H. Hirsch, M.S. Alphey, Susan Lauw, +7

Organic & Biomolecular Chemistry

Isoprenoid biosynthesis in plants – 2<i>C</i>‐methyl‐<scp>d</scp>‐erythritol‐4‐phosphate synthase (IspC protein) of <i>Arabidopsis thaliana</i>

Felix Rohdich, Susan Lauw, J. Kaiser, +4

FEBS Journal

Plant PhysiologyEngineeringMolecular BiologyPlant Molecular BiologyBiosynthesis +14

Fluorescent Inhibitors for IspF, an Enzyme in the Non‐Mevalonate Pathway for Isoprenoid Biosynthesis and a Potential Target for Antimalarial Therapy

Christine M. Crane, J. Kaiser, Nicola L. Ramsden, +6

Angewandte Chemie International Edition

Bioorganic ChemistryAntiparasitic AgentAffinity Towards IspfSecondary MetaboliteChemical Biology +14

Characterization of <i>Aquifex aeolicus</i> 4‐diphosphocytidyl‐2<i>C</i>‐methyl‐<scp>d</scp>‐erythritol kinase – ligand recognition in a template for antimicrobial drug discovery

Tanja Sgraja, M.S. Alphey, Stephanos Ghilagaber, +8

FEBS Journal

Synthesis and Characterization of Cytidine Derivatives that Inhibit the Kinase IspE of the Non‐Mevalonate Pathway for Isoprenoid Biosynthesis

Christine M. Crane, Anna K. H. Hirsch, M.S. Alphey, +8

ChemMedChem

Anti-malarial drug targets: Screening for inhibitors of 2C-methyl-d-erythritol 4-phosphate synthase (IspC protein) in Mediterranean plants

J. Kaiser, Mohamed A. Yassin, Satya Prakash, +9

Phytomedicine

Inhibitory ActivityBiochemistryAntiparasitic AgentMedicineMalaria +6

Structure‐Based Design and Synthesis of the First Weak Non‐Phosphate Inhibitors for IspF, an Enzyme in the Non‐Mevalonate Pathway of Isoprenoid Biosynthesis

Corinne Baumgartner, Christian Eberle, François Diederich, +4

Helvetica Chimica Acta

Antiparasitic AgentMalariaParasite GenomicsDiversity Oriented SynthesisBiosynthesis +15

Cross-talk between Type Three Secretion System and Metabolism in Yersinia

Annika Schmid, Wibke Neumayer, Konrad Trülzsch, +10

Journal of Biological Chemistry

Protein SecretionMicrobial PathogensBacterial PathogensYscm2 BindSecretion System +14