Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53

Megan J. Bywater, Gretchen Poortinga, Elaine Sanij, +20

Cancer Cell

Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation

Per Hydbring, Fuad Bahram, Yingtao Su, +12

Proceedings of the National Academy of Sciences

Activated MycCell DeathCell CycleCdk2 ActivityCancer Biology +17

First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study

Amit Khot, Natalie Brajanovski, Donald P. Cameron, +15

Cancer Discovery

Identification of<i>Burkholderia pseudomallei</i>Genes Required for the Intracellular Life Cycle and In Vivo Virulence

Sabine Pilatz, Katrin Breitbach, Nadine Hein, +5

Infection and Immunity

Protein SecretionGeneticsBacteriologyBacteriophageMolecular Biology +18

Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma

Jennifer R. Devlin, Katherine M. Hannan, Nadine Hein, +15

Cancer Discovery

Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling

Jaclyn Quin, Keefe T. Chan, Jennifer R. Devlin, +17

Oncotarget

Peter MacMolecular BiologyCell DeathGene TranscriptionTumor Biology +17

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

Nadine Hein, Donald P. Cameron, Katherine M. Hannan, +27

Blood

A novel role for the Pol I transcription factor UBTF in maintaining genome stability through the regulation of highly transcribed Pol II genes

Elaine Sanij, Jeannine Diesch, Analia Lesmana, +14

Genome Research

Histone ModificationsGeneticsGenomic MechanismMolecular BiologyMolecular Genetics +20

Nuclear stabilization of p53 requires a functional nucleolar surveillance pathway

Katherine M. Hannan, Priscilla Soo, Mei Wong, +29

Cell Reports

Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation

Jeannine Diesch, Megan J. Bywater, Elaine Sanij, +13

Communications Biology