Natalie Brajanovski

CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer

Elaine Sanij, Katherine M. Hannan, Jiachen Xuan et al. · Nature Communications · 2020 · 219 citations · Full text

Life Sciences, Cancer Biology, Oncology +17

First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study

Amit Khot, Natalie Brajanovski, Donald P. Cameron et al. · Cancer Discovery · 2019 · 203 citations

Medicine, Oncology, Pharmacology +15

Regulation of PRMT5–MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma

Shatha AbuHammad, Carleen Cullinane, Claire Martin et al. · Proceedings of the National Academy of Sciences · 2019 · 124 citations · Full text

Medicine, Molecular Biology, Oncology +17

Palbociclib synergizes with BRAF and MEK inhibitors in treatment naïve melanoma but not after the development of BRAF inhibitor resistance

Claire Martin, Carleen Cullinane, Laura Kirby et al. · International Journal of Cancer · 2017 · 72 citations

Medicine, Oncology, Pharmacology +14

Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation

Jeannine Diesch, Megan J. Bywater, Elaine Sanij et al. · Communications Biology · 2019 · 47 citations · Full text

Life Sciences, Genetics, Molecular Biology +17