Concepedia

Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53

Megan J. Bywater, Gretchen Poortinga, Elaine Sanij, Nadine Hein, Abigail Peck, Carleen Cullinane, Meaghan Wall, Leonie A. Cluse, Denis Drygin, Kenna Anderes,

Cancer Cell · 2012 · 560 citations · 24 references

DOIFull text

Open access

Concepts

References

24

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

Jerry M. Adams, A. W. Harris, Carl A. Pinkert et al. · Nature · 1985 · 1.8K citations

, , +16

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

Christine M. Eischen, Jason D. Weber, Martine F. Roussel et al. · Genes & Development · 1999 · 826 citations · Full text

, , +17

Systematic Identification of Pathways That Couple Cell Growth and Division in Yeast

Paul Jorgensen, Joy L. Nishikawa, Bobby‐Joe Breitkreutz et al. · Science · 2002 · 804 citations

, , +17

c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I

Carla Grandori, Natividad Gomez-Roman, Zoë A. Felton-Edkins et al. · Nature Cell Biology · 2005 · 664 citations

, , +17

Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth

Denis Drygin, Amy Lin, Josh Bliesath et al. · Cancer Research · 2010 · 621 citations

, , +17