Dietmar Hoffmann

Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699

Paul R. August, Li Tang, Yeo Joon Yoon et al. · Chemistry & Biology · 1998 · 348 citations · Full text

Biosynthesis, Engineering, Biotransformation +10

The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from <i>Actinosynnema</i> <i>pretiosum</i>

Tin‐Wein Yu, Linquan Bai, Dorothee Clade et al. · Proceedings of the National Academy of Sciences · 2002 · 282 citations · Full text

Glutaminase is essential for the growth of triple-negative breast cancer cells with a deregulated glutamine metabolism pathway and its suppression synergizes with mTOR inhibition

Michael Lampa, Heike Arlt, Timothy He et al. · PLoS ONE · 2017 · 156 citations · Full text

Breast Oncology, Tumor Cells, Metabolic Remodeling +18

Selective Inhibition of Mutant Isocitrate Dehydrogenase 1 (IDH1) via Disruption of a Metal Binding Network by an Allosteric Small Molecule

Gejing Deng, Junqing Shen, Ming Yin et al. · Journal of Biological Chemistry · 2014 · 135 citations · Full text

Sequence analysis and biochemical characterization of the nostopeptolide A biosynthetic gene cluster from Nostoc sp. GSV224

Dietmar Hoffmann, Joan M. Hevel, Richard E. Moore et al. · Gene · 2003 · 119 citations

Biosynthesis, Engineering, Biochemistry +7