Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699

Paul R. August, Li Tang, Yeo Joon Yoon, +9

Chemistry & Biology

BiosynthesisEngineeringBiotransformationBiochemistryBiochemical Taxonomy +8

The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from <i>Actinosynnema</i> <i>pretiosum</i>

Tin‐Wein Yu, Linquan Bai, Dorothee Clade, +7

Proceedings of the National Academy of Sciences

Glutaminase is essential for the growth of triple-negative breast cancer cells with a deregulated glutamine metabolism pathway and its suppression synergizes with mTOR inhibition

Michael Lampa, Heike Arlt, Timothy He, +14

PLoS ONE

Breast OncologyTumor CellsMetabolic RemodelingCancer BiologyTumor Biology +16

Selective Inhibition of Mutant Isocitrate Dehydrogenase 1 (IDH1) via Disruption of a Metal Binding Network by an Allosteric Small Molecule

Gejing Deng, Junqing Shen, Ming Yin, +23

Journal of Biological Chemistry

Sequence analysis and biochemical characterization of the nostopeptolide A biosynthetic gene cluster from Nostoc sp. GSV224

Dietmar Hoffmann, Joan M. Hevel, Richard E. Moore, +1

Gene

BiosynthesisEngineeringBiochemistryNostoc SpSequence Analysis +5

Biosynthesis of 4-Methylproline in Cyanobacteria:  Cloning of <i>n</i><i>osE</i> and <i>n</i><i>osF</i> Genes and Biochemical Characterization of the Encoded Dehydrogenase and Reductase Activities

Hendrik Luesch, Dietmar Hoffmann, Joan M. Hevel, +3

The Journal of Organic Chemistry

EngineeringEscherichia ColiCyanobacteriaUnusual AminoBiosynthesis +14

An increase of hippocampal calretinin-immunoreactive neurons correlates with early febrile seizures in temporal lobe epilepsy

Ingmar Blümcke, Heinz Beck, Bernhard Suter, +6

Acta Neuropathologica

Synaptic PlasticitySynaptic SignalingNeurophysiologyNeuroanatomyTemporal Lobe Epilepsy +8

SAR439859, a Novel Selective Estrogen Receptor Degrader (SERD), Demonstrates Effective and Broad Antitumor Activity in Wild-Type and Mutant ER-Positive Breast Cancer Models

Maysoun Shomali, Jane Cheng, Fangxian Sun, +27

Molecular Cancer Therapeutics

Identification of the endosomal sorting complex required for transport-I (ESCRT-I) as an important modulator of anti-miR uptake by cancer cells

Timothy R. Wagenaar, Tatiana Tolstykh, Chaomei Shi, +22

Nucleic Acids Research

Extracellular MicrovesiclesEndosomal Sorting ComplexCancer BiologyTumor BiologyMolecular Sorting +15

PIM inhibitors target CD25-positive AML cells through concomitant suppression of STAT5 activation and degradation of MYC oncogene

Zhuyan Guo, Anlai Wang, Weidong Zhang, +19

Blood