Timothy He

Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion

Kensuke Tateishi, Hiroaki Wakimoto, A. John Iafrate et al. · Cancer Cell · 2015 · 439 citations · Full text

Genome Instability, Cancer Genomics, Extreme Vulnerability +4

Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells

Taiping Chen, Sarah Hevi, Frédérique Gay et al. · Nature Genetics · 2007 · 348 citations

Tumor Biology, Genome Instability, Cell Regulation +12

Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing

Heinz Linhart, Haijiang Lin, Yasuhiro Yamada et al. · Genes & Development · 2007 · 271 citations · Full text

Glutaminase is essential for the growth of triple-negative breast cancer cells with a deregulated glutamine metabolism pathway and its suppression synergizes with mTOR inhibition

Michael Lampa, Heike Arlt, Timothy He et al. · PLoS ONE · 2017 · 156 citations · Full text

Breast Oncology, Tumor Cells, Metabolic Remodeling +18

Towards Prediction of In Vivo Intestinal Absorption Using a 96-Well Caco-2 Assay

Suzanne Skolnik, Xuena Lin, Jianling Wang et al. · Journal of Pharmaceutical Sciences · 2010 · 147 citations

Biochemistry, Medicine, Bioanalysis +11