The YTA10–12 Complex, an AAA Protease with Chaperone-like Activity in the Inner Membrane of Mitochondria

Heike Arlt, Raimund Tauer, Horst Feldmann, +2

Cell

Yta10–12 ComplexProtein FunctionAaa ProteaseBiochemistryInner Membrane +7

Molecular chaperones cooperate with PIM1 protease in the degradation of misfolded proteins in mitochondria.

Ingrid Wagner, Heike Arlt, Luc van Dyck, +2

The EMBO Journal

Pim1 ProteaseMolecular ChaperonesMitochondrial FunctionBiochemistryProtein Folding +10

Glutaminase is essential for the growth of triple-negative breast cancer cells with a deregulated glutamine metabolism pathway and its suppression synergizes with mTOR inhibition

Michael Lampa, Heike Arlt, Timothy He, +14

PLoS ONE

Breast OncologyTumor CellsMetabolic RemodelingCancer BiologyTumor Biology +16

Elacestrant (RAD1901), a Selective Estrogen Receptor Degrader (SERD), Has Antitumor Activity in Multiple ER+ Breast Cancer Patient-derived Xenograft Models

Teeru Bihani, Hitisha Patel, Heike Arlt, +6

Clinical Cancer Research

Functional interaction between the human cytomegalovirus 86-kilodalton IE2 protein and the cellular transcription factor CREB

Dieter Lang, Stephanie Gebert, Heike Arlt, +1

Journal of Virology

Transcriptional RegulationViral ReplicationMolecular VirologyNatural Sciences86-Kda Ie2 Protein +12

Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents

Guy Griebel, Philippe Pichat, Sandra Beeské, +28

Scientific Reports

Identification of binding sites for the 86-kilodalton IE2 protein of human cytomegalovirus within an IE2-responsive viral early promoter

Heike Arlt, Dieter Lang, Stephanie Gebert, +1

Journal of Virology

Ie2 ProteinMolecular BiologyViral Structural Protein86-Kilodalton Ie2 ProteinCancer-associated Virus +17

Elacestrant (RAD1901) exhibits anti-tumor activity in multiple ER+ breast cancer models resistant to CDK4/6 inhibitors

Hitisha Patel, Nianjun Tao, Kyung-Min Lee, +6

Breast Cancer Research

Anti–miR-21 Suppresses Hepatocellular Carcinoma Growth via Broad Transcriptional Network Deregulation

Timothy R. Wagenaar, Sonya Zabludoff, Sung‐Min Ahn, +25

Molecular Cancer Research

Identification of the endosomal sorting complex required for transport-I (ESCRT-I) as an important modulator of anti-miR uptake by cancer cells

Timothy R. Wagenaar, Tatiana Tolstykh, Chaomei Shi, +22

Nucleic Acids Research

Extracellular MicrovesiclesEndosomal Sorting ComplexCancer BiologyTumor BiologyMolecular Sorting +15