Gejing Deng

Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion

Kensuke Tateishi, Hiroaki Wakimoto, A. John Iafrate et al. · Cancer Cell · 2015 · 439 citations · Full text

Genome Instability, Cancer Genomics, Extreme Vulnerability +4

Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques

Ling Xu, Amarendra Pegu, Ercole Rao et al. · Science · 2017 · 266 citations · Full text

Immunology, Effective Aids Vaccine, Antiviral Drug +16

Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation

Lan Wu, Edward Seung, Ling Xu et al. · Nature Cancer · 2019 · 232 citations

Tumor Immunology, Tumor-directed T Cells, Cancer Immunosurveillance +8

Glutaminase is essential for the growth of triple-negative breast cancer cells with a deregulated glutamine metabolism pathway and its suppression synergizes with mTOR inhibition

Michael Lampa, Heike Arlt, Timothy He et al. · PLoS ONE · 2017 · 156 citations · Full text

Breast Oncology, Tumor Cells, Metabolic Remodeling +18

A trispecific antibody targeting HER2 and T cells inhibits breast cancer growth via CD4 cells

Edward Seung, Zhen Xing, Lan Wu et al. · Nature · 2022 · 144 citations

Trispecific Antibody, Breast Cancer Growth, Breast Oncology +7