Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion

Kensuke Tateishi, Hiroaki Wakimoto, A. John Iafrate, +26

Cancer Cell

Genome InstabilityCancer GenomicsExtreme VulnerabilityCancer GeneticsMedicine +2

Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques

Ling Xu, Amarendra Pegu, Ercole Rao, +34

Science

ImmunologyEffective Aids VaccineAntiviral DrugImmunotherapyTrispecific Abs +14

Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation

Lan Wu, Edward Seung, Ling Xu, +32

Nature Cancer

Tumor ImmunologyTumor-directed T CellsCancer ImmunosurveillanceImmunologyTherapeutic Efficacy +6

Glutaminase is essential for the growth of triple-negative breast cancer cells with a deregulated glutamine metabolism pathway and its suppression synergizes with mTOR inhibition

Michael Lampa, Heike Arlt, Timothy He, +14

PLoS ONE

Breast OncologyTumor CellsMetabolic RemodelingCancer BiologyTumor Biology +16

A trispecific antibody targeting HER2 and T cells inhibits breast cancer growth via CD4 cells

Edward Seung, Zhen Xing, Lan Wu, +25

Nature

Trispecific AntibodyBreast Cancer GrowthBreast OncologyImmunologyAntigen Processing +5

Amino acid sequence of a new type of antifreeze protein, from the longhorn sculpin <i>Myoxocephalus octodecimspinosis</i>

Gejing Deng, David W. Andrews, Richard A. Laursen

FEBS Letters

Selective Inhibition of Mutant Isocitrate Dehydrogenase 1 (IDH1) via Disruption of a Metal Binding Network by an Allosteric Small Molecule

Gejing Deng, Junqing Shen, Ming Yin, +23

Journal of Biological Chemistry

Discovery of LFF571: An Investigational Agent for <i>Clostridium difficile</i> Infection

Matthew J. LaMarche, Jennifer A. Leeds, Adam Amaral, +26

Journal of Medicinal Chemistry

Bioorganic ChemistryBacteriophageInvestigational AgentBacterial PathogensPharmaceutical Chemistry +18

Multiple cyclophilins involved in different cellular pathways mediate HCV replication

L. Alex Gaither, Jason Borawski, Leah J. Anderson, +16

Virology

Viral ReplicationCell DivisionNatural SciencesPathogenesisMolecular Biology +4

Lys6-modified Ubiquitin Inhibits Ubiquitin-dependent Protein Degradation

Fu Shang, Gejing Deng, Qing Liu, +5

Journal of Biological Chemistry