Susan B. Gates

LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes.

C Shih, V J Chen, Lynn S. Gossett et al. · PubMed · 1997 · 565 citations

Multiple Folate-requiring Enzymes, Medicinal Chemistry, Biochemistry +14

Enzyme inhibition, polyglutamation, and the effect of LY231514 (MTA) on purine biosynthesis.

L G Mendelsohn, Chwen-Ming Shih, V. J. Chen et al. · PubMed · 1999 · 102 citations

Multi-targeted antifolates aimed at avoiding drug resistance form covalent closed inhibitory complexes with human and Escherichia coli thymidylate synthases

Peter H. Sayre, Janet Finer-Moore, Timothy A. Fritz et al. · Journal of Molecular Biology · 2001 · 60 citations

Biochemistry, Medicine, Natural Sciences +10

Characterization of folate receptor from normal and neoplastic murine tissue: influence of dietary folate on folate receptor expression.

Susan B. Gates, Laurane G. Mendelsohn, Katherine A. Shackelford et al. · PubMed · 1996 · 41 citations

Liver Fr, Folate Receptor, Oncology +14

The role of dietary folate in modulation of folate receptor expression, folylpolyglutamate synthetase activity and the efficacy and toxicity of lometrexol

Laurane G. Mendelsohn, Susan B. Gates, Lillian L. Habeck et al. · Advances in Enzyme Regulation · 1996 · 27 citations

Biochemistry, Medicine, Dietary Folate +6