Frank J. Bruzzese - Concepedia

Concepedia

Author

Frank J. Bruzzese

Millennium Engineering and Integration (United States)

Also Known As

F J Bruzzese, Frank Bruzzese, Frank J. Bruzzese, Frank J. Bruzzese

41

Publications

2.1K

Citations

14

H-Index

40

Concepts

All Affiliations

Millennium Engineering and Integration (United States)Vertex Pharmaceuticals (United States)Takeda (United States)

FJ

About

Frank J. Bruzzese is an author at Millennium Engineering and Integration (United States) specializing in biochemistry, natural sciences, and medicine.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	9	9	1.3K
2	Natural Sciences	9	9	940
3	Biochemistry	9	9	940
4	Health Sciences	1	1	488
5	Biomolecular Engineering	1	1	414

Frank J. Bruzzese

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14

Publications

2.1K

Citations

14

H-Index

	Year	Citations
Evaluation of the Proteasome Inhibitor MLN9708 in Preclinical Models of Human Cancer Erik Kupperman, Edmund C. Lee, Yueying Cao, Cancer Research Proteasome Inhibitor Mln9708Antitumor ActivityImmunologyProteasomeMolecular Biology	2010	488
Substrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ James E. Brownell, Michael D. Sintchak, James M. Gavin, Molecular Cell Protein ChemistryNedd8-amp MimeticProtein FunctionBiochemistryProtein Folding	2010	457
A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment Marc L. Hyer, Michael A. Milhollen, Jeff Ciavarri, Nature Medicine MedicineAnti-cancer AgentSmall-molecule InhibitorDrug DevelopmentBiomolecular Engineering	2018	414
Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S β5-subunit Christopher Blackburn, Kenneth M. Gigstad, Paul Hales, Biochemical Journal	2010	144
Enthalpy of hydrogen bond formation in aprotein-ligand binding reaction. Patrick R. Connelly, Robert A. Aldape, Frank J. Bruzzese, Proceedings of the National Academy of Sciences Protein ChemistryBiochemistryProtein FoldingMedicineNatural Sciences	1994	134
Mechanistic Studies of Substrate-assisted Inhibition of Ubiquitin-activating Enzyme by Adenosine Sulfamate Analogues Jesse J. Chen, Christopher Tsu, James M. Gavin, Journal of Biological Chemistry Mechanistic StudiesAldo-keto ReductaseBiochemistryMedicineAdenosine Sulfamate Analogues	2011	92
Comparison of biochemical and biological effects of ML858 (salinosporamide A) and bortezomib Mark J. Williamson, Jonathan L. Blank, Frank J. Bruzzese, Molecular Cancer Therapeutics	2006	72
Target Validation and Identification of Novel Boronate Inhibitors of the <i>Plasmodium falciparum</i> Proteasome Stanley C. Xie, David L. Gillett, Natalie J. Spillman, Journal of Medicinal Chemistry Drug TargetAntiparasitic AgentMalariaMolecular BiologyPharmaceutical Chemistry	2018	72
Mechanistic Study of Uba5 Enzyme and the Ufm1 Conjugation Pathway James M. Gavin, Kara M. Hoar, Qing Xu, Journal of Biological Chemistry Protein FunctionCellular EnzymologyBiochemistryProtein FoldingNatural Sciences	2014	47
Probing hydration contributions to the thermodynamics of ligand binding by proteins. Enthalpy and heat capacity changes of tacrolimus and rapamycin binding to FK506 binding protein in deuterium oxide and water Patrick R. Connelly, John A. Thomson, Matthew J. Fitzgibbon, Biochemistry	1993	46

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