Frank J. Bruzzese

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Publications

Citations

2.1K

H-Index

Active since

1993

Affiliations

Millennium Engineering and Integration (United States)(Current)

Vertex Pharmaceuticals (United States)

Takeda (United States)

Frank J. Bruzzese is an author at Millennium Engineering and Integration (United States) specializing in biochemistry, enzyme inhibition, and enzymology.

Publications per year

1993–2018

Publications

Evaluation of the Proteasome Inhibitor MLN9708 in Preclinical Models of Human Cancer

Erik Kupperman, Edmund C. Lee, Yueying Cao et al. · Cancer Research · 2010 · 493 citations

Medicine, Oncology, Pharmacology +13

Substrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ

James E. Brownell, Michael D. Sintchak, James M. Gavin et al. · Molecular Cell · 2010 · 461 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment

Marc L. Hyer, Michael A. Milhollen, Jeff Ciavarri et al. · Nature Medicine · 2018 · 456 citations

Pharmacy, Medicinal Chemistry, Oncology +14

Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S β5-subunit

Christopher Blackburn, Kenneth M. Gigstad, Paul Hales et al. · Biochemical Journal · 2010 · 146 citations · Full text

Pharmacy, Biochemistry, Medicinal Chemistry +14

Enthalpy of hydrogen bond formation in aprotein-ligand binding reaction.

Patrick R. Connelly, Robert A. Aldape, Frank J. Bruzzese et al. · Proceedings of the National Academy of Sciences · 1994 · 137 citations · Full text

Natural Sciences, Biochemistry, Chemistry +17

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