P. Dan Cook

Evaluation of 2‘-modified oligonucleotides containing 2‘-deoxy gaps as antisense inhibitors of gene expression

Brett P. Monia, Elena A. Lesnik, C. Gonzalez et al. · Journal of Biological Chemistry · 1993 · 766 citations · Full text

Rnase H, Bioorganic Chemistry, Biochemistry +13

Uniformly modified 2'-deoxy-2'-fluoro-phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets

Andrew M. Kawasaki, Martin D. Casper, Susan M. Freier et al. · Journal of Medicinal Chemistry · 1993 · 432 citations

Bioorganic Chemistry, Molecular Biology, Duplex Stability +16

Characterization of fully 2'-modified oligoribonucleotide hetero- and homoduplex hybridization and nuclease sensitivity

Lendell L. Cummins, Stephen R. Owens, Lisa M. Risen et al. · Nucleic Acids Research · 1995 · 359 citations · Full text

Dna Nanotechnology, Modified Homoduplexes, Biochemistry +13

Oligodeoxynucleotides containing 2'-O-modified adenosine: Synthesis and effects on stability of DNA:RNA duplexes

Elena A. Lesnik, Charles J. Guinosso, Andrew M. Kawasaki et al. · Biochemistry · 1993 · 201 citations

Dna Nanotechnology, Nucleic Acid Chemistry, Biochemistry +15

Structure−Activity Relationship of Purine Ribonucleosides for Inhibition of Hepatitis C Virus RNA-Dependent RNA Polymerase

Anne B. Eldrup, Charles Allerson, C. Frank Bennett et al. · Journal of Medicinal Chemistry · 2004 · 187 citations · Full text

Medicinal Chemistry, Viral Replication, Biochemistry +15