Charles J. Guinosso

Evaluation of 2‘-modified oligonucleotides containing 2‘-deoxy gaps as antisense inhibitors of gene expression

Brett P. Monia, Elena A. Lesnik, C. Gonzalez et al. · Journal of Biological Chemistry · 1993 · 766 citations · Full text

Rnase H, Bioorganic Chemistry, Biochemistry +13

Characterization of fully 2'-modified oligoribonucleotide hetero- and homoduplex hybridization and nuclease sensitivity

Lendell L. Cummins, Stephen R. Owens, Lisa M. Risen et al. · Nucleic Acids Research · 1995 · 359 citations · Full text

Dna Nanotechnology, Modified Homoduplexes, Biochemistry +13

Pharmacokinetic properties of several novel oligonucleotide analogs in mice.

Stanley T. Crooke, Melissa Graham, J E Zuckerman et al. · Journal of Pharmacology and Experimental Therapeutics · 1996 · 228 citations

Oligodeoxynucleotides containing 2'-O-modified adenosine: Synthesis and effects on stability of DNA:RNA duplexes

Elena A. Lesnik, Charles J. Guinosso, Andrew M. Kawasaki et al. · Biochemistry · 1993 · 201 citations

Dna Nanotechnology, Nucleic Acid Chemistry, Biochemistry +15

2‘-<i>O</i>-Aminopropyl Ribonucleotides:  A Zwitterionic Modification That Enhances the Exonuclease Resistance and Biological Activity of Antisense Oligonucleotides

Richard H. Griffey, Brett P. Monia, Lendall L. Cummins et al. · Journal of Medicinal Chemistry · 1996 · 127 citations

Nucleic Acid Chemistry, Bioorganic Chemistry, Sugar Proton Resonances +15