Elena A. Lesnik

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Publications

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4.5K

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Active since

1969

Affiliations

Ionis Pharmaceuticals (United States)(Current)

Vanderbilt University

Elena A. Lesnik is an author at Ionis Pharmaceuticals (United States) specializing in molecular biology, nucleic acid biochemistry, and oligonucleotide chemistry.

Publications per year

1969–2005

Publications

Evaluation of 2‘-modified oligonucleotides containing 2‘-deoxy gaps as antisense inhibitors of gene expression

Brett P. Monia, Elena A. Lesnik, C. Gonzalez et al. · Journal of Biological Chemistry · 1993 · 770 citations · Full text

Life Sciences, Cancer Biology, Molecular Biology +16

Uniformly modified 2'-deoxy-2'-fluoro-phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets

Andrew M. Kawasaki, Martin D. Casper, Susan M. Freier et al. · Journal of Medicinal Chemistry · 1993 · 436 citations

Life Sciences, Molecular Biology, Bioorthogonal Chemistry +16

2′-O-(2-Methoxy)ethyl-modified Anti-intercellular Adhesion Molecule 1 (ICAM-1) Oligonucleotides Selectively Increase the ICAM-1 mRNA Level and Inhibit Formation of the ICAM-1 Translation Initiation Complex in Human Umbilical Vein Endothelial Cells

Brenda F. Baker, Sidney S. Lot, Thomas P. Condon et al. · Journal of Biological Chemistry · 1997 · 377 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15

Characterization of fully 2'-modified oligoribonucleotide hetero- and homoduplex hybridization and nuclease sensitivity

Lendell L. Cummins, Stephen R. Owens, Lisa M. Risen et al. · Nucleic Acids Research · 1995 · 361 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Relative Thermodynamic Stability of DNA, RNA, and DNA:RNA Hybrid Duplexes: Relationship with Base Composition and Structure

Elena A. Lesnik, Susan M. Freier · Biochemistry · 1995 · 293 citations

Life Sciences, Biochemistry, Molecular Biology +17

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