Andrés Berdeja

Fully 2‘-Modified Oligonucleotide Duplexes with Improved in Vitro Potency and Stability Compared to Unmodified Small Interfering RNA

Charles Allerson, Namir Sioufi, Russell Jarres et al. · Journal of Medicinal Chemistry · 2005 · 440 citations

Vitro Potency, Stability Compared, Small Interfering Rna +13

Synthesis and Biophysical Evaluation of 2′,4′-Constrained 2′<i>O</i>-Methoxyethyl and 2′,4′-Constrained 2′<i>O</i>-Ethyl Nucleic Acid Analogues

Punit P. Seth, Guillermo Vasquez, Charles A. Allerson et al. · The Journal of Organic Chemistry · 2010 · 208 citations

Bioorganic Chemistry, Engineering, 2',4'-Constrained Moe +17

Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages

Wei Wan, Michael T. Migawa, Guillermo Vasquez et al. · Nucleic Acids Research · 2014 · 127 citations · Full text

Biological Activity, Medicinal Chemistry, Bioorganic Chemistry +12

Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides

Brooke A. Anderson, Graeme C. Freestone, Audrey Low et al. · Nucleic Acids Research · 2021 · 121 citations · Full text

Dna Gap, Gene Therapies, Novel Therapy +15

Widespread recognition of 5′ splice sites by noncanonical base-pairing to U1 snRNA involving bulged nucleotides

Xavier Roca, Martin Akerman, Hans Gaus et al. · Genes & Development · 2012 · 102 citations · Full text