Graeme C. Freestone

Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides

Brooke A. Anderson, Graeme C. Freestone, Audrey Low et al. · Nucleic Acids Research · 2021 · 131 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +17

New synthetic technology for the construction of N-hydroxyindoles and synthesis of nocathiacin I model systems

K. C. Nicolaou, Anthony A. Estrada, Graeme C. Freestone et al. · Tetrahedron · 2007 · 53 citations · Full text

Pharmacy, Biotechnology, Medicinal Chemistry +7

Design and Synthesis of Novel and Selective Phosphodiesterase 2 (PDE2a) Inhibitors for the Treatment of Memory Disorders

Laurent Gomez, Mark E. Massari, Troy Vickers et al. · Journal of Medicinal Chemistry · 2017 · 53 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Site-specific incorporation of 5′-methyl DNA enhances the therapeutic profile of gapmer ASOs

Guillermo Vasquez, Graeme C. Freestone, Audrey Low et al. · Nucleic Acids Research · 2021 · 47 citations · Full text

Medicine, Molecular Biology, Pharmacology +13

Synthesis of Highly Substituted <i>N</i>‐Hydroxyindoles through 1,5‐Addition of Carbon Nucleophiles to In Situ Generated Unsaturated Nitrones

K. C. Nicolaou, Anthony A. Estrada, Sang Hyup Lee et al. · Angewandte Chemie International Edition · 2006 · 39 citations

Natural Sciences, Chemistry, Catalysis +8