Audrey Low

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary<i>N</i>-acetyl galactosamine improves potency 10-fold in mice

Thazha P. Prakash, Mark J. Graham, Jinghua Yu et al. · Nucleic Acids Research · 2014 · 579 citations · Full text

Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index

Wen Shen, Cheryl Li De Hoyos, Michael T. Migawa et al. · Nature Biotechnology · 2019 · 308 citations

Protein Function, Signal Transduction, Biochemistry +13

Peripheral Androgen Receptor Gene Suppression Rescues Disease in Mouse Models of Spinal and Bulbar Muscular Atrophy

Andrew P. Lieberman, Zhigang Yu, Sue Murray et al. · Cell Reports · 2014 · 173 citations · Full text

Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle

Thazha P. Prakash, Adam E. Mullick, Richard Lee et al. · Nucleic Acids Research · 2019 · 142 citations · Full text

Comprehensive Structure–Activity Relationship of Triantennary<i>N</i>-Acetylgalactosamine Conjugated Antisense Oligonucleotides for Targeted Delivery to Hepatocytes

Thazha P. Prakash, Jinghua Yu, Michael T. Migawa et al. · Journal of Medicinal Chemistry · 2016 · 131 citations