Ryuichi Kiyama

Carbamoyl Pyridone HIV-1 Integrase Inhibitors 3. A Diastereomeric Approach to Chiral Nonracemic Tricyclic Ring Systems and the Discovery of Dolutegravir (S/GSK1349572) and (S/GSK1265744)

Brian A. Johns, Takashi Kawasuji, Jason G. Weatherhead et al. · Journal of Medicinal Chemistry · 2013 · 184 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Ligand−Protein DataBase:  Linking Protein−Ligand Complex Structures to Binding Data

Olivier Roche, Ryuichi Kiyama, Charles L. Brooks · Journal of Medicinal Chemistry · 2001 · 133 citations

Life Sciences, Bioinformatics, Medicinal Chemistry +15

Homology Modeling of Gelatinase Catalytic Domains and Docking Simulations of Novel Sulfonamide Inhibitors

Ryuichi Kiyama, Yoshinori Tamura, Fumihiko Watanabe et al. · Journal of Medicinal Chemistry · 1999 · 97 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +17

Carbamoyl Pyridone HIV-1 Integrase Inhibitors. 2. Bi- and Tricyclic Derivatives Result in Superior Antiviral and Pharmacokinetic Profiles

Takashi Kawasuji, Brian A. Johns, Hiroshi Yoshida et al. · Journal of Medicinal Chemistry · 2013 · 92 citations

Pharmacy, Medicinal Chemistry, Pharmacology +13

A platform for designing HIV integrase inhibitors. Part 2: A two-metal binding model as a potential mechanism of HIV integrase inhibitors

Takashi Kawasuji, Masahiro Fuji, Tomokazu Yoshinaga et al. · Bioorganic & Medicinal Chemistry · 2006 · 82 citations

Pharmacy, Medicinal Chemistry, Molecular Biology +16