Highly Selective and Orally Active Inhibitors of Type IV Collagenase (MMP-9 and MMP-2):  <i>N</i>-Sulfonylamino Acid Derivatives

Yoshinori Tamura, Fumihiko Watanabe, Takuji Nakatani, +9

Journal of Medicinal Chemistry

Pharmaceutical SciencePharmacotherapyChemical BiologyPharmaceutical ChemistryMolecular Pharmacology +16

Carbamoyl Pyridone HIV-1 Integrase Inhibitors 3. A Diastereomeric Approach to Chiral Nonracemic Tricyclic Ring Systems and the Discovery of Dolutegravir (S/GSK1349572) and (S/GSK1265744)

Brian A. Johns, Takashi Kawasuji, Jason G. Weatherhead, +18

Journal of Medicinal Chemistry

Medicinal ChemistryBioorganic ChemistryBiochemistryMedicineIntegrase Inhibitors +13

The Transition Metal-Catalyzed Intermolecular [5+2] Cycloaddition:  The Homologous Diels−Alder Reaction

Paul A. Wender, Heiko Rieck, Masahiro Fuji

Journal of the American Chemical Society

Chemical EngineeringCross-coupling ReactionEngineeringHomologous Diels−alder ReactionAlkene Metathesis +8

Rhodium-Catalyzed [5 + 2] Cycloadditions of Allenes and Vinylcyclopropanes:  Asymmetric Total Synthesis of (+)-Dictamnol

Paul A. Wender, Masahiro Fuji, Craig O. Husfeld, +1

Organic Letters

Chemical EngineeringMedicinal ChemistryAsymmetric Total SynthesisEngineeringHeterocyclic +12

Carbamoyl Pyridone HIV-1 Integrase Inhibitors. 2. Bi- and Tricyclic Derivatives Result in Superior Antiviral and Pharmacokinetic Profiles

Takashi Kawasuji, Brian A. Johns, Hiroshi Yoshida, +15

Journal of Medicinal Chemistry

Antiviral CompoundMedicineImmunologyAntiviral Drug DevelopmentPharmacokinetic Profiles +12

A platform for designing HIV integrase inhibitors. Part 2: A two-metal binding model as a potential mechanism of HIV integrase inhibitors

Takashi Kawasuji, Masahiro Fuji, Tomokazu Yoshinaga, +3

Bioorganic & Medicinal Chemistry

Two-metal Binding ModelMedicineAntiviral Drug DevelopmentRational Drug DesignMolecular Biology +8

3-Hydroxy-1,5-dihydro-pyrrol-2-one derivatives as advanced inhibitors of HIV integrase

Takashi Kawasuji, Masahiro Fuji, Tomokazu Yoshinaga, +3

Bioorganic & Medicinal Chemistry

Medicinal ChemistryHiv IntegraseMedicineAntiviral Drug DevelopmentPharmacotherapy +5

Carbamoyl Pyridone HIV-1 Integrase Inhibitors. 1. Molecular Design and Establishment of an Advanced Two-Metal Binding Pharmacophore

Takashi Kawasuji, Brian A. Johns, Hiroshi Yoshida, +10

Journal of Medicinal Chemistry

Pk BoosterPharmacotherapyAntiviral DrugPharmaceutical ChemistryNovel Chelating Scaffold +20

Total Synthesis of Terprenin, a Highly Potent and Novel Immunoglobulin E Antibody Suppressant

Kenji Kawada, Akinori Arimura, Tatsuo Tsuri, +13

Angewandte Chemie International Edition

Proper LinkageImmunologyOrganic ChemistryChemistryHeterocycle Chemistry +15

Synthesis and Antiviral Activity of 7-Benzyl-4-hydroxy-1,5-naphthyridin-2(1<i>H</i>)-one HIV Integrase Inhibitors

Eric E. Boros, Cynthia E. Edwards, Scott A. Foster, +18

Journal of Medicinal Chemistry