Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: A platform for antiviral drug design

Yehuda Goldgur, Robert Craigie, Gerson H. Cohen, +7

Proceedings of the National Academy of Sciences

Hiv IntegraseMolecular BiologyAntiviral DrugMedicinal ChemistryAntiviral Drug Development +15

<i>In Vitro</i>Antiretroviral Properties of S/GSK1349572, a Next-Generation HIV Integrase Inhibitor

Masanori Kobayashi, Tomokazu Yoshinaga, Takahiro Seki, +15

Antimicrobial Agents and Chemotherapy

NeurovirologyDrug DiscoveryMedicineImmunologyHuman Retrovirus +12

In vitro characterization of baloxavir acid, a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit

Takeshi Noshi, Mitsutaka Kitano, K. Taniguchi, +17

Antiviral Research

Vitro CharacterizationBiochemistryNatural SciencesImmunologyAntiviral Drug Development +9

Carbamoyl Pyridone HIV-1 Integrase Inhibitors 3. A Diastereomeric Approach to Chiral Nonracemic Tricyclic Ring Systems and the Discovery of Dolutegravir (S/GSK1349572) and (S/GSK1265744)

Brian A. Johns, Takashi Kawasuji, Jason G. Weatherhead, +18

Journal of Medicinal Chemistry

Medicinal ChemistryBioorganic ChemistryBiochemistryMedicineIntegrase Inhibitors +13

HIV‐1 integrase inhibitory substances from <i>Coleus parvifolius</i>

Supinya Tewtrakul, Hirotsugu Miyashiro, Norio Nakamura, +9

Phytotherapy Research

Antiviral Characteristics of GSK1265744, an HIV Integrase Inhibitor Dosed Orally or by Long-Acting Injection

Tomokazu Yoshinaga, Masanori Kobayashi, Takahiro Seki, +11

Antimicrobial Agents and Chemotherapy

Carbamoyl Pyridone HIV-1 Integrase Inhibitors. 2. Bi- and Tricyclic Derivatives Result in Superior Antiviral and Pharmacokinetic Profiles

Takashi Kawasuji, Brian A. Johns, Hiroshi Yoshida, +15

Journal of Medicinal Chemistry

Antiviral CompoundMedicineImmunologyAntiviral Drug DevelopmentPharmacokinetic Profiles +12

A platform for designing HIV integrase inhibitors. Part 2: A two-metal binding model as a potential mechanism of HIV integrase inhibitors

Takashi Kawasuji, Masahiro Fuji, Tomokazu Yoshinaga, +3

Bioorganic & Medicinal Chemistry

Two-metal Binding ModelMedicineAntiviral Drug DevelopmentRational Drug DesignMolecular Biology +8

3-Hydroxy-1,5-dihydro-pyrrol-2-one derivatives as advanced inhibitors of HIV integrase

Takashi Kawasuji, Masahiro Fuji, Tomokazu Yoshinaga, +3

Bioorganic & Medicinal Chemistry

Medicinal ChemistryHiv IntegraseMedicineAntiviral Drug DevelopmentPharmacotherapy +5

The Naphthyridinone GSK364735 Is a Novel, Potent Human Immunodeficiency Virus Type 1 Integrase Inhibitor and Antiretroviral

Edward P. Garvey, Brian A. Johns, Margaret Gartland, +20

Antimicrobial Agents and Chemotherapy

Naphthyridinone Gsk364735MedicineHuman RetrovirusImmunologyAntiviral Drug Development +11