In vitro characterization of baloxavir acid, a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit

Takeshi Noshi, Mitsutaka Kitano, K. Taniguchi, +17

Antiviral Research

Vitro CharacterizationBiochemistryNatural SciencesImmunologyAntiviral Drug Development +9

Combination treatment with the cap-dependent endonuclease inhibitor baloxavir marboxil and a neuraminidase inhibitor in a mouse model of influenza A virus infection

Keita Fukao, Takeshi Noshi, Atsuko Yamamoto, +8

Journal of Antimicrobial Chemotherapy

Hydroxypropyl-β-Cyclodextrin Spikes Local Inflammation That Induces Th2 Cell and T Follicular Helper Cell Responses to the Coadministered Antigen

Motoyasu Onishi, Koji Ozasa, Kouji Kobiyama, +21

The Journal of Immunology

Baloxavir marboxil, a novel cap-dependent endonuclease inhibitor potently suppresses influenza virus replication and represents therapeutic effects in both immunocompetent and immunocompromised mouse models

Keita Fukao, Yoshinori Ando, Takeshi Noshi, +7

PLoS ONE

VaccinationAllergyVirus TiterBaloxavir MarboxilMedicine +9

Efficacy of Single Intravenous Injection of Peramivir against Influenza B Virus Infection in Ferrets and Cynomolgus Macaques

Mitsutaka Kitano, Yasushi Itoh, Makoto Kodama, +12

Antimicrobial Agents and Chemotherapy

Protective Efficacy of Passive Immunization with Monoclonal Antibodies in Animal Models of H5N1 Highly Pathogenic Avian Influenza Virus Infection

Yasushi Itoh, Reiko Yoshida, Shintaro Shichinohe, +23

PLoS Pathogens

VaccinationProtective EfficacyVaccine DevelopmentAllergyPassive Immunization +11

Protection against H5N1 Highly Pathogenic Avian and Pandemic (H1N1) 2009 Influenza Virus Infection in Cynomolgus Monkeys by an Inactivated H5N1 Whole Particle Vaccine

Misako Nakayama, Shintaro Shichinohe, Yasushi Itoh, +16

PLoS ONE

VaccinationVaccine DevelopmentAllergyCynomolgus MonkeysH5n1 Hpaiv +11

Pathogenicity of Pandemic H1N1 Influenza A Virus in Immunocompromised Cynomolgus Macaques

Van Loi Pham, Misako Nakayama, Yasushi Itoh, +12

PLoS ONE

VaccinationInfluenza Virus SpreadAllergyVirus EpidemiologyImmunosuppressed Macaques +12

Efficacy of Repeated Intravenous Administration of Peramivir against Highly Pathogenic Avian Influenza A (H5N1) Virus in Cynomolgus Macaques

Mitsutaka Kitano, Yasushi Itoh, Hirohito Ishigaki, +13

Antimicrobial Agents and Chemotherapy

Repeated Intravenous AdministrationImmunologyAntiviral Drug DevelopmentAntiviral TherapyVirology +8

Establishment of a cynomolgus macaque model of influenza B virus infection

Mitsutaka Kitano, Yasushi Itoh, Makoto Kodama, +10

Virology

Cynomolgus Macaque ModelViral PathogenesisImmunologyViral DynamicVirology +2