Mitsunori Kato

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

Ying-Nan P. Chen, Matthew J. LaMarche, Ho Man Chan et al. · Nature · 2016 · 893 citations

Cancer Research, Allosteric Inhibition, Signal Transduction +12

Polarizable Force Fields:  History, Test Cases, and Prospects

Arieh Warshel, Mitsunori Kato, Andrei V. Pisliakov · Journal of Chemical Theory and Computation · 2007 · 379 citations

Polarizable Force Fields, Biophysical Modeling, Electrohydrodynamics +16

Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor

Jorge Fortanet, Christine Hiu-Tung Chen, Ying-Nan P. Chen et al. · Journal of Medicinal Chemistry · 2016 · 284 citations · Full text

Allosteric Inhibition, Drug Target, Shp2 Inhibition +20

Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer

Matthew J. LaMarche, Michael Acker, Andreea Argintaru et al. · Journal of Medicinal Chemistry · 2020 · 207 citations · Full text

Small-molecule WNK inhibition regulates cardiovascular and renal function

Ken Yamada, Hyi-Man Park, Dean F. Rigel et al. · Nature Chemical Biology · 2016 · 162 citations · Full text

Molecular Physiology, Kidney Research, Medicine +8