Kouki Fuchino

Structure-Based Design of Selective β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: Targeting the Flap to Gain Selectivity over BACE2

Kazuki Fujimoto, Eriko Matsuoka, Naoya Asada et al. · Journal of Medicinal Chemistry · 2019 · 35 citations · Full text

Drug Target, Protein Assembly, Molecular Biology +17

Rational Design of Novel 1,3-Oxazine Based β-Secretase (BACE1) Inhibitors: Incorporation of a Double Bond To Reduce P-gp Efflux Leading to Robust Aβ Reduction in the Brain

Kouki Fuchino, Yasunori Mitsuoka, Moriyasu Masui et al. · Journal of Medicinal Chemistry · 2018 · 33 citations · Full text

Discovery of Potent and Centrally Active 6-Substituted 5-Fluoro-1,3-dihydro-oxazine β-Secretase (BACE1) Inhibitors via Active Conformation Stabilization

Kenji Nakahara, Kouki Fuchino, Kazuo Komano et al. · Journal of Medicinal Chemistry · 2018 · 32 citations · Full text

Chemical Biology, Pharmaceutical Chemistry, Pre-clinical Pharmacology +20

Structure-Based Approaches to Improving Selectivity through Utilizing Explicit Water Molecules: Discovery of Selective β-Secretase (BACE1) Inhibitors over BACE2

Kazuki Fujimoto, Shuhei Yoshida, Genta Tadano et al. · Journal of Medicinal Chemistry · 2021 · 23 citations · Full text

Pyrrolinone derivatives as a new class of P2X3 receptor antagonists Part 2: Discovery of orally bioavailable compounds

Hiroyuki Tobinaga, Takayuki Kameyama, Kentarou Asahi et al. · Bioorganic & Medicinal Chemistry Letters · 2019 · 11 citations · Full text

Pharmaceutical Science, Biochemistry, Medicine +8