Kouki Fuchino - Concepedia

Author

Kouki Fuchino

Shionogi (Japan)

Also Known As

Fuchino, Kouki, K. Fuchino, Kouki Fuchino

Publications

155

Citations

H-Index

Concepts

All Affiliations

Shionogi (Japan)Futaba (Japan)Janssen (Belgium)

About

Kouki Fuchino is an author at Shionogi (Japan) specializing in drug discovery, medicine, and pharmacology.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	3	3	78
2	Biochemistry	3	3	78
3	Natural Sciences	2	2	67
4	Chemical Biology	2	2	67
5	Molecular Biology	1	1	35

Kouki Fuchino

Publications

144

Citations

H-Index

Page 1

	Year	Citations
Structure-Based Design of Selective β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: Targeting the Flap to Gain Selectivity over BACE2 Kazuki Fujimoto, Eriko Matsuoka, Naoya Asada, Journal of Medicinal Chemistry Drug TargetProtein AssemblyMolecular BiologyChemical BiologyPharmaceutical Chemistry	2019	35
Rational Design of Novel 1,3-Oxazine Based β-Secretase (BACE1) Inhibitors: Incorporation of a Double Bond To Reduce P-gp Efflux Leading to Robust Aβ Reduction in the Brain Kouki Fuchino, Yasunori Mitsuoka, Moriyasu Masui, Journal of Medicinal Chemistry	2018	33
Discovery of Potent and Centrally Active 6-Substituted 5-Fluoro-1,3-dihydro-oxazine β-Secretase (BACE1) Inhibitors via Active Conformation Stabilization Kenji Nakahara, Kouki Fuchino, Kazuo Komano, Journal of Medicinal Chemistry Chemical BiologyPharmaceutical ChemistryPre-clinical PharmacologyMolecular PharmacologyMedicinal Chemistry	2018	32
Structure-Based Approaches to Improving Selectivity through Utilizing Explicit Water Molecules: Discovery of Selective β-Secretase (BACE1) Inhibitors over BACE2 Kazuki Fujimoto, Shuhei Yoshida, Genta Tadano, Journal of Medicinal Chemistry	2021	23
Pyrrolinone derivatives as a new class of P2X3 receptor antagonists Part 2: Discovery of orally bioavailable compounds Hiroyuki Tobinaga, Takayuki Kameyama, Kentarou Asahi, Bioorganic & Medicinal Chemistry Letters Pharmaceutical ScienceBiochemistryMedicinePharmacological AgentNew Class	2019	11
Discovery of an Extremely Potent Thiazine-Based β-Secretase Inhibitor with Reduced Cardiovascular and Liver Toxicity at a Low Projected Human Dose Genta Tadano, Kazuo Komano, Shuhei Yoshida, Journal of Medicinal Chemistry	2019	10

Page 1