Naoya Asada

Structure–Activity Relationships of Carboline and Carbazole Derivatives as a Novel Class of ATP-Competitive Kinesin Spindle Protein Inhibitors

Tomoki Takeuchi, Shinya Oishi, Toshiaki Watanabe et al. · Journal of Medicinal Chemistry · 2011 · 79 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +17

The Use of Many-Body Expansions and Geometry Optimizations in Fragment-Based Methods

Dmitri G. Fedorov, Naoya Asada, Isao Nakanishi et al. · Accounts of Chemical Research · 2014 · 73 citations

Natural Sciences, Chemistry, Computational Chemistry +15

Discovery of Atabecestat (JNJ-54861911): A Thiazine-Based β-Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor Advanced to the Phase 2b/3 EARLY Clinical Trial

Yuji Koriyama, Akihiro Hori, Hisanori Ito et al. · Journal of Medicinal Chemistry · 2021 · 54 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Structure-Based Design of Selective β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: Targeting the Flap to Gain Selectivity over BACE2

Kazuki Fujimoto, Eriko Matsuoka, Naoya Asada et al. · Journal of Medicinal Chemistry · 2019 · 40 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of Potent and Centrally Active 6-Substituted 5-Fluoro-1,3-dihydro-oxazine β-Secretase (BACE1) Inhibitors via Active Conformation Stabilization

Kenji Nakahara, Kouki Fuchino, Kazuo Komano et al. · Journal of Medicinal Chemistry · 2018 · 34 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17