Kazuki Fujimoto

Structure-Based Design of Selective β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: Targeting the Flap to Gain Selectivity over BACE2

Kazuki Fujimoto, Eriko Matsuoka, Naoya Asada et al. · Journal of Medicinal Chemistry · 2019 · 40 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Structure-Based Approaches to Improving Selectivity through Utilizing Explicit Water Molecules: Discovery of Selective β-Secretase (BACE1) Inhibitors over BACE2

Kazuki Fujimoto, Shuhei Yoshida, Genta Tadano et al. · Journal of Medicinal Chemistry · 2021 · 26 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Discovery of an Extremely Potent Thiazine-Based β-Secretase Inhibitor with Reduced Cardiovascular and Liver Toxicity at a Low Projected Human Dose

Genta Tadano, Kazuo Komano, Shuhei Yoshida et al. · Journal of Medicinal Chemistry · 2019 · 10 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17