Concepedia

Pyrrolinone derivatives as a new class of P2X3 receptor antagonists Part 2: Discovery of orally bioavailable compounds

Hiroyuki Tobinaga, Takayuki Kameyama, Kentarou Asahi, Tohru Horiguchi, Miho Oohara, Yukio Tada, Kouki Fuchino, Sae Jikihara, Takeshi Endoh, Naoko Kurihara,

Bioorganic & Medicinal Chemistry Letters · 2019 · 11 citations · 7 references

DOIFull text

Open access

Concepts

References

7

A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury

Ze’ev Seltzer, Ronald Dubner, Yoram Shir · Pain · 1990 · 1.8K citations

, , +17

Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice

Debra A. Cockayne, Sara G. Hamilton, Quan‐Ming Zhu et al. · Nature · 2000 · 1K citations

, , +15

A P2X purinoceptor expressed by a subset of sensory neurons

Chih‐Cheng Chen, Armen N. Akopian, Lucia G. Sivilotti et al. · Nature · 1995 · 1K citations

, , +14

Crystal structure of the ATP-gated P2X4 ion channel in the closed state

Toshimitsu Kawate, Jennifer Carlisle Michel, William T. Birdsong et al. · Nature · 2009 · 742 citations · Full text

, , +16

P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study

Rayid Abdulqawi, Rachel Dockry, Kimberley Holt et al. · The Lancet · 2014 · 483 citations

, , +10