Christian Berk

Type III CRISPR–Cas systems produce cyclic oligoadenylate second messengers

Ole Niewoehner, Carmela Garcia‐Doval, Jakob T. Rostøl et al. · Nature · 2017 · 490 citations

Natural Sciences, Molecular Biology, Genetic Engineering +6

Covalent linkage of the DNA repair template to the CRISPR-Cas9 nuclease enhances homology-directed repair

Nataša Savić, Femke Ringnalda, Helen Lindsay et al. · eLife · 2018 · 163 citations · Full text

Crispr-cas9 Nuclease, Genetics, Molecular Biology +16

Activation and self-inactivation mechanisms of the cyclic oligoadenylate-dependent CRISPR ribonuclease Csm6

Carmela Garcia‐Doval, Frank Schwede, Christian Berk et al. · Nature Communications · 2020 · 100 citations · Full text

In vivo cytidine base editing of hepatocytes without detectable off-target mutations in RNA and DNA

Lukas Villiger, Tanja Rothgangl, Dominik Witzigmann et al. · Nature Biomedical Engineering · 2021 · 97 citations · Full text

Chromatin, Rna Processing, Natural Sciences +11

Synthesis and cellular activity of stereochemically-pure 2′-O-(2-methoxyethyl)-phosphorothioate oligonucleotides

Meiling Li, Helen L. Lightfoot, François Halloy et al. · Chemical Communications · 2016 · 48 citations

Bioorganic Chemistry, Engineering, Molecular Biology +16