Type III CRISPR–Cas systems produce cyclic oligoadenylate second messengers

Ole Niewoehner, Carmela Garcia‐Doval, Jakob T. Rostøl, +6

Nature

Natural SciencesMolecular BiologyGenetic EngineeringGenome EngineeringGene Editing +4

Covalent linkage of the DNA repair template to the CRISPR-Cas9 nuclease enhances homology-directed repair

Nataša Savić, Femke Ringnalda, Helen Lindsay, +9

eLife

Crispr-cas9 NucleaseGeneticsMolecular BiologyCovalent LinkageMolecular Genetics +14

Activation and self-inactivation mechanisms of the cyclic oligoadenylate-dependent CRISPR ribonuclease Csm6

Carmela Garcia‐Doval, Frank Schwede, Christian Berk, +6

Nature Communications

In vivo cytidine base editing of hepatocytes without detectable off-target mutations in RNA and DNA

Lukas Villiger, Tanja Rothgangl, Dominik Witzigmann, +14

Nature Biomedical Engineering

ChromatinRna ProcessingNatural SciencesLiver PhysiologyRna Biology +9

Synthesis and cellular activity of stereochemically-pure 2′-O-(2-methoxyethyl)-phosphorothioate oligonucleotides

Meiling Li, Helen L. Lightfoot, François Halloy, +5

Chemical Communications

Bioorganic ChemistryEngineeringMolecular BiologyChemical BiologyMedicinal Chemistry +14

One- and Two-Dimensional High-Resolution NMR from Flat Surfaces

Brennan J. Walder, Christian Berk, Wei‐Chih Liao, +7

ACS Central Science

Pharmacodynamic and Pharmacokinetic Properties of Full Phosphorothioate Small Interfering RNAs for Gene Silencing <i>In Vivo</i>

Christian Berk, Gianluca Civenni, Yuluan Wang, +3

Nucleic Acid Therapeutics

Pharmacological inhibition of Lin28 promotes ketogenesis and restores lipid homeostasis in models of non-alcoholic fatty liver disease

Evangelia Lekka, Aleksandra Kokanovic, Simone Mosole, +8

Nature Communications

Pharmacological InhibitionFatty Liver DiseaseLin28 InhibitionMetabolic SyndromeTranscriptional Regulation +19

In vitro Generation of CRISPR-Cas9 Complexes with Covalently Bound Repair Templates for Genome Editing in Mammalian Cells

Nataša Savić, Femke Ringnalda, Christian Berk, +4

BIO-PROTOCOL

Site-specific conjugation of drug-like fragments to an antimiR scaffold as a strategy to target miRNAs inside RISC

Andreas Brunschweiger, Luca F. R. Gebert, Matije Lucic, +5

Chemical Communications

Medicinal ChemistryEngineeringMedicineDrug DiscoveryRna Biology +13