Helen L. Lightfoot

LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans

Nicolas J. Lehrbach, Javier Armisen, Helen L. Lightfoot et al. · Nature Structural & Molecular Biology · 2009 · 232 citations · Full text

Transcriptional Regulation, Developmental Biology, Rna Biology +7

Synthesis and cellular activity of stereochemically-pure 2′-O-(2-methoxyethyl)-phosphorothioate oligonucleotides

Meiling Li, Helen L. Lightfoot, François Halloy et al. · Chemical Communications · 2016 · 48 citations

Bioorganic Chemistry, Engineering, Molecular Biology +16

A LIN28-Dependent Structural Change in pre-let-7g Directly Inhibits Dicer Processing

Helen L. Lightfoot, Anthony Bugaut, Javier Armisen et al. · Biochemistry · 2011 · 42 citations · Full text

Rna Processing, Systems Biology, Signal Transduction +14

Identification of small molecule inhibitors of the Lin28-mediated blockage of pre-let-7g processing

Helen L. Lightfoot, Eric A. Miska, Shankar Balasubramanian · Organic & Biomolecular Chemistry · 2016 · 38 citations · Full text

Target mRNA inhibition by oligonucleotide drugs in man

Helen L. Lightfoot, Jonathan Hall · Nucleic Acids Research · 2012 · 36 citations · Full text