Frank Schwede

A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK

Jorrit M. Enserink, Anne Elisabeth Christensen, Johan de Rooij et al. · Nature Cell Biology · 2002 · 690 citations

Signal Transduction, Signaling Pathway, Cell Regulation +10

Type III CRISPR–Cas systems produce cyclic oligoadenylate second messengers

Ole Niewoehner, Carmela Garcia‐Doval, Jakob T. Rostøl et al. · Nature · 2017 · 490 citations

Natural Sciences, Molecular Biology, Genetic Engineering +6

cAMP Analog Mapping of Epac1 and cAMP Kinase

Anne Elisabeth Christensen, Frode Selheim, Johan de Rooij et al. · Journal of Biological Chemistry · 2003 · 399 citations · Full text

Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation

Bryan A. Gibson, Yajie Zhang, Hong Jiang et al. · Science · 2016 · 371 citations · Full text

Genetics, Molecular Biology, Molecular Genetics +20

Epac-selective cAMP Analog 8-pCPT-2′-O-Me-cAMP as a Stimulus for Ca2+-induced Ca2+ Release and Exocytosis in Pancreatic β-Cells

Guoxin Kang, Jamie W. Joseph, Oleg G. Chepurny et al. · Journal of Biological Chemistry · 2003 · 296 citations · Full text

Second Messenger Camp, Insulin Signaling, Cellular Physiology +19