Christopher E. Whitehead

Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition

Jeffrey F. Ohren, Huifen Chen, A.G. Pavlovsky et al. · Nature Structural & Molecular Biology · 2004 · 621 citations

Life Sciences, Biochemistry, Molecular Biology +9

Wild-type EGFR Is Stabilized by Direct Interaction with HSP90 in Cancer Cells and Tumors

Aarif Ahsan, Susmita G. Ramanand, Christopher E. Whitehead et al. · Neoplasia · 2012 · 96 citations · Full text

Medicine, Cancer Biology, Oncology +17

KRAS Protein Stability Is Regulated through SMURF2: UBCH5 Complex-Mediated β-TrCP1 Degradation

Shirish Shukla, Uday Sankar Allam, Aarif Ahsan et al. · Neoplasia · 2014 · 96 citations · Full text

Life Sciences, Cancer Biology, Genetics +13

2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles—O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase)

Joseph S. Warmus, Cathlin Flamme, Lu Yan Zhang et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 67 citations

Medicine, Medicinal Chemistry, Pharmacology +9

Transferable atom equivalent multicentered multipole expansion method

Christopher E. Whitehead, Curt M. Breneman, N. Sukumar et al. · Journal of Computational Chemistry · 2003 · 61 citations

Natural Sciences, Chemistry, Biomolecular Modeling +14