Michael J. Bower

Prediction of protein side-chain rotamers from a backbone-dependent rotamer library: a new homology modeling tool

Michael J. Bower, Fred E. Cohen, Roland L. Dunbrack · Journal of Molecular Biology · 1997 · 561 citations

Life Sciences, Bioinformatics, Biology +13

INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology

Eddy W. Yue, Richard Sparks, Padmaja Polam et al. · ACS Medicinal Chemistry Letters · 2017 · 296 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +8

Acquisition of Sensitivity of Stress-activated Protein Kinases to the p38 Inhibitor, SB 203580, by Alteration of One or More Amino Acids within the ATP Binding Pocket

Rebecca J. Gum, Megan M. McLaughlin, Sanjay Kumar et al. · Journal of Biological Chemistry · 1998 · 227 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +16

Discovery of Potent Competitive Inhibitors of Indoleamine 2,3-Dioxygenase with in Vivo Pharmacodynamic Activity and Efficacy in a Mouse Melanoma Model

Eddy W. Yue, Brent Douty, Brian Wayland et al. · Journal of Medicinal Chemistry · 2009 · 217 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +9

Structural Basis for Chk1 Inhibition by UCN-01

Baoguang Zhao, Michael J. Bower, Patrick McDevitt et al. · Journal of Biological Chemistry · 2002 · 206 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +17