Albert Amegadzie

Discovery of a Covalent Inhibitor of KRAS^G12C (AMG 510) for the Treatment of Solid Tumors

Brian A. Lanman, Jennifer R. Allen, John G. Allen et al. · Journal of Medicinal Chemistry · 2019 · 677 citations · Full text

Drug Target, Solid Tumors, Molecular Biology +20

Affinity and cooperativity modulate ternary complex formation to drive targeted protein degradation

Ryan P. Wurz, Huan Rui, Ken Dellamaggiore et al. · Nature Communications · 2023 · 103 citations · Full text

One-Pot Synthesis of 3-Triazolyl-2-iminochromenes via a Catalytic Three Component Cascade Reaction

Wenyuan Qian, Albert Amegadzie, David J. Winternheimer et al. · Organic Letters · 2013 · 47 citations

Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious β-secretase inhibitors for the potential treatment of Alzheimer’s disease

Jian Jeffrey Chen, Qingyian Liu, Chester Yuan et al. · Bioorganic & Medicinal Chemistry Letters · 2015 · 29 citations · Full text

Alzheimer's Disease, Medicine, 2-Aminooxazoline 3-Azaxanthenes +9

Discovery of 2-methylpyridine-based biaryl amides as γ-secretase modulators for the treatment of Alzheimer’s disease

Jian Jeffrey Chen, Wenyuan Qian, Kaustav Biswas et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 15 citations · Full text

Medicinal Chemistry, Neurodegenerative Diseases, Alzheimer's Disease +14