Chester Yuan

Fulvestrant-3 Boronic Acid (ZB716): An Orally Bioavailable Selective Estrogen Receptor Downregulator (SERD)

Jiawang Liu, Shilong Zheng, Victoria Akerstrom et al. · Journal of Medicinal Chemistry · 2016 · 81 citations · Full text

Breast Oncology, Gynecology, Pharmacotherapy +17

Discovery of TRPM8 Antagonist (<i>S</i>)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine

Daniel B. Horne, Kaustav Biswas, James Brown et al. · Journal of Medicinal Chemistry · 2018 · 60 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Trpm8 Antagonist +15

2-(<i>S</i>)-Phenethylaminothiazolones as Potent, Orally Efficacious Inhibitors of 11β-Hydroxysteriod Dehydrogenase Type 1

David J. St. Jean, Chester Yuan, Eric A. Bercot et al. · Journal of Medicinal Chemistry · 2007 · 50 citations · Full text

The discovery of 2-anilinothiazolones as 11β-HSD1 inhibitors

Chester Yuan, David J. St. Jean, Qingyian Liu et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 41 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Drug Target +7

Cytochrome P450-Mediated Epoxidation of 2-Aminothiazole-Based AKT Inhibitors: Identification of Novel GSH Adducts and Reduction of Metabolic Activation through Structural Changes Guided by in Silico and in Vitro Screening

Raju Subramanian, Matthew R. Lee, John G. Allen et al. · Chemical Research in Toxicology · 2010 · 30 citations

Medicinal Chemistry, Novel Gsh Adducts, Biochemistry +15