David J. St. Jean

From Fragment Screening to In Vivo Efficacy: Optimization of a Series of 2-Aminoquinolines as Potent Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1)

Yuan Cheng, Ted Judd, Michael D. Bartberger et al. · Journal of Medicinal Chemistry · 2011 · 136 citations · Full text

Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors

David J. Lloyd, David J. St. Jean, Robert J. Kurzeja et al. · Nature · 2013 · 96 citations

Biochemistry, Medicine, Insulin Management +6

Discovery of a Potent, Orally Active 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor for Clinical Study: Identification of (<i>S</i>)-2-((1<i>S</i>,2<i>S</i>,4<i>R</i>)-Bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5<i>H</i>)-one (AMG 221)

Murielle M. Véniant, Clarence Hale, Randall W. Hungate et al. · Journal of Medicinal Chemistry · 2010 · 80 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Methyl Group +14

Toward a General Route to the Eunicellin Diterpenes:  The Asymmetric Total Synthesis of Deacetoxyalcyonin Acetate

Gary A. Molander, David J. St. Jean, Julia Haas · Journal of the American Chemical Society · 2004 · 70 citations

Bioorganic Chemistry, Engineering, Organic Chemistry +16

A Tandem Cross-Coupling/S_NAr Approach to Functionalized Carbazoles

David J. St. Jean, Steve F. Poon, Jamie L. Schwarzbach · Organic Letters · 2007 · 64 citations

Cross-coupling Reaction, Engineering, Functionalized Carbazoles +11