Jian Jeffrey Chen

Discovery of a Covalent Inhibitor of KRAS^G12C (AMG 510) for the Treatment of Solid Tumors

Brian A. Lanman, Jennifer R. Allen, John G. Allen et al. · Journal of Medicinal Chemistry · 2019 · 677 citations · Full text

Drug Target, Solid Tumors, Molecular Biology +20

In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B.

Murray J. Towle, Kathleen A. Salvato, John Budrow et al. · PubMed · 2001 · 491 citations

Vivo Anticancer Activities, Medicinal Chemistry, Heterocyclic +13

Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways

Kent Miner, Katja Labitzke, Benxian Liu et al. · Frontiers in Pharmacology · 2019 · 132 citations · Full text

Fragmentation of substituted acetophenones and halobenzophenone ketyls. Calibration of a mechanistic probe

Dennis D. Tanner, Jian Jeffrey Chen, Lucia Chen et al. · Journal of the American Chemical Society · 1991 · 82 citations

Halogenation, Chemical Measurement, Engineering +14

On the mechanism of the reduction of .alpha.-haloketones by 1,3-dimethyl-2-phenylbenzimidazoline. Reduction by a SET (single electron transfer)-hydrogen atom abstraction chain mechanism

Dennis D. Tanner, Jian Jeffrey Chen · The Journal of Organic Chemistry · 1989 · 61 citations

Halogenation, Chemical Engineering, Engineering +15