Richard K. Frisbie

Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms

Matthew F. Calabrese, Francis Rajamohan, Melissa S. Harris et al. · Structure · 2014 · 180 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Discovery of Clinical Candidate 1-{[(2 <i>S</i> ,3 <i>S</i> ,4 <i>S</i> )-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design

Katherine L. Lee, Catherine M. Ambler, David R. Anderson et al. · Journal of Medicinal Chemistry · 2017 · 145 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1<i>H</i>-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy

Kimberly O. Cameron, Daniel W. Kung, Amit S. Kalgutkar et al. · Journal of Medicinal Chemistry · 2016 · 117 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15

Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators

Francis Rajamohan, Allan R. Reyes, Richard K. Frisbie et al. · Biochemical Journal · 2015 · 66 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Synthesis and SAR of 1,2,3,4-tetrahydroisoquinolin-1-ones as novel G-protein-coupled receptor 40 (GPR40) antagonists

Paul S. Humphries, John W. Benbow, Paul D. Bonin et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 51 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +12