Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms

Matthew F. Calabrese, Francis Rajamohan, Melissa S. Harris, +24

Structure

Opposite PolesMolecular PhysiologySignal TransductionBiochemistrySignaling Pathway +7

Structural comparison of chromosomal and exogenous dihydrofolate reductase from <i>Staphylococcus aureus</i> in complex with the potent inhibitor trimethoprim

H. Heaslet, Melissa S. Harris, Kelly Fahnoe, +6

Proteins Structure Function and Bioinformatics

Inhibitors of HCV NS5B polymerase. Part 1: Evaluation of the southern region of (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid

Jeffrey A. Pfefferkorn, Meredith Greene, Richard A. Nugent, +10

Bioorganic & Medicinal Chemistry Letters

Hcv Ns5b PolymeraseAcrylic AcidMedicineAntiviral Drug DevelopmentAntiviral Therapy +7

Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors

Zhigang Wang, William Watt, Nathan A. Brooks, +11

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Medicinal ChemistryCaspase-8 InhibitionBiochemistryMedicineNatural Sciences +6

A Short-Term, Quasi-Experimental Evaluation of D.A.R.E.'s Revised Elementary School Curriculum

Amy A. Vincus, Chris Ringwalt, Melissa S. Harris, +1

Journal of Drug Education

Thermodynamic and Structure Guided Design of Statin Based Inhibitors of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase

Ronald W. Sarver, Elizabeth Bills, Gary L. Bolton, +10

Journal of Medicinal Chemistry

Medicinal ChemistryBiochemistryCardiovascular DiseaseStructure Guided DesignStatin Inhibitors +13

A Structural Variation for MurB:  X-ray Crystal Structure of <i>Staphylococcus aureus </i>UDP-<i>N</i>-Acetylenolpyruvylglucosamine Reductase (MurB)

Timothy E. Benson, Melissa S. Harris, Gil H. Choi, +4

Biochemistry

Substituted Pyrazoles as Hepatoselective HMG-CoA Reductase Inhibitors: Discovery of (3<i>R</i>,5<i>R</i>)-7-[2-(4-Fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2<i>H</i>-pyrazol-3-yl]-3,5-dihydroxyheptanoic Acid (PF-3052334) as a Candidate for the Treatment of Hypercholesterolemia

Jeffrey A. Pfefferkorn, Chulho Choi, Scott D. Larsen, +16

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistrySubstituted PyrazolesHmg-coa Reductase InhibitorsAldo-keto Reductase +13

Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors

Jeffrey A. Pfefferkorn, Yuntao Song, Kuai-Lin Sun, +27

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesPharmacology +3

Crystal Structure of Type II Peptide Deformylase from Staphylococcus aureus

Eric T. Baldwin, Melissa S. Harris, Anthony W. Yem, +10

Journal of Biological Chemistry