H. Heaslet

A Copper(I)-Catalyzed 1,2,3-Triazole Azide−Alkyne Click Compound Is a Potent Inhibitor of a Multidrug-Resistant HIV-1 Protease Variant

Michael J. Giffin, H. Heaslet, Ashraf Brik et al. · Journal of Medicinal Chemistry · 2008 · 244 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +17

Structural comparison of chromosomal and exogenous dihydrofolate reductase from <i>Staphylococcus aureus</i> in complex with the potent inhibitor trimethoprim

H. Heaslet, Melissa S. Harris, Kelly Fahnoe et al. · Proteins Structure Function and Bioinformatics · 2009 · 139 citations

Medicine, Biochemistry, Pharmacology +10

Conformational flexibility in the flap domains of ligand-free HIV protease

H. Heaslet, R.J. Rosenfeld, Mike Giffin et al. · Acta Crystallographica Section D Biological Crystallography · 2007 · 100 citations

Life Sciences, Biochemistry, Molecular Biology +15

Characterization of the active site of S. aureus monofunctional glycosyltransferase (Mtg) by site-directed mutation and structural analysis of the protein complexed with moenomycin

H. Heaslet, Bailin Shaw, Anil Mistry et al. · Journal of Structural Biology · 2009 · 57 citations

Life Sciences, Biochemistry, Molecular Biology +12

Crystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-3

H. Heaslet, Ying‐Chuan Lin, Karen Tam et al. · Retrovirology · 2007 · 43 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17