Carl Thibeault

Conformationally Constrained <i>ortho-</i>Anilino Diaryl Ureas: Discovery of 1-(2-(1′-Neopentylspiro[indoline-3,4′-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a Potent, Selective, and Bioavailable P2Y₁ Antagonist

Jennifer X. Qiao, Tammy C. Wang, Réjean Ruel et al. · Journal of Medicinal Chemistry · 2013 · 70 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Aligning Potency and Pharmacokinetic Properties for Pyridine-Based NCINIs

Lee D. Fader, Murray D. Bailey, Eric Beaulieu et al. · ACS Medicinal Chemistry Letters · 2016 · 25 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Identification of 1-{2-[4-chloro-1′-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4′-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y1 antagonist as an antiplatelet agent

Yoon Jeon, Wu Yang, Jennifer X. Qiao et al. · Bioorganic & Medicinal Chemistry Letters · 2014 · 19 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +6

Discovery and preclinical studies of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737), an in vivo active potent VEGFR-2 inhibitor

Réjean Ruel, Carl Thibeault, Alexandre L’Heureux et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 19 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +11

Potent P2Y1 urea antagonists bearing various cyclic amine scaffolds

Réjean Ruel, Alexandre L’Heureux, Carl Thibeault et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 10 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +7