An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus

Daniel Lamarre, Paul C. Anderson, Murray D. Bailey, +25

Nature

Antiviral EffectsHepatologyHepatitis C VirusViral HepatitisNs3 Protease Inhibitor +7

Unexpected Intermolecular Pd-Catalyzed Cross-Coupling Reaction Employing Heteroaromatic Carboxylic Acids as Coupling Partners

Pat Forgione, Marie‐Christine Brochu, Miguel St‐Onge, +3

Journal of the American Chemical Society

EngineeringOrganic ChemistryChemistryMedicinal ChemistrySelective Transformation +14

Structure−Activity Study on a Novel Series of Macrocyclic Inhibitors of the Hepatitis C Virus NS3 Protease Leading to the Discovery of BILN 2061

Montse Llinàs‐Brunet, Murray D. Bailey, Gordon T. Bolger, +14

Journal of Medicinal Chemistry

Competitive Hexapeptide InhibitorsPharmacotherapyAntiviral DrugPharmaceutical ChemistryDrug Resistance +14

Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1

Lee D. Fader, Éric Malenfant, Mathieu Parisien, +32

ACS Medicinal Chemistry Letters

Hiv-1 IntegraseImmunologyMolecular BiologyPharmacotherapyBi 224436 +14

Peptide-based inhibitors of the hepatitis C virus serine protease

Montse Llinàs‐Brunet, Murray D. Bailey, Gulrez Fazal, +9

Bioorganic & Medicinal Chemistry Letters

BiochemistryNatural SciencesAntiviral Drug DevelopmentAntiviral TherapyPeptide-based Inhibitors +5

A Systematic Approach to the Optimization of Substrate-Based Inhibitors of the Hepatitis C Virus NS3 Protease:  Discovery of Potent and Specific Tripeptide Inhibitors

Montse Llinàs‐Brunet, Murray D. Bailey, Élise Ghiro, +5

Journal of Medicinal Chemistry

Peptide SubstratesAntiviral DrugChemical BiologyCompetitive Peptide InhibitorsMedicinal Chemistry +19

Highly potent and selective peptide-based inhibitors of the hepatitis C virus serine protease: towards smaller inhibitors

Montse Llinàs‐Brunet, Murray D. Bailey, Gulrez Fazal, +11

Bioorganic & Medicinal Chemistry Letters

BiochemistryMedicineAntiviral Drug DevelopmentHighly PotentHepatitis +7

Synthesis of BILN 2061, an HCV NS3 Protease Inhibitor with Proven Antiviral Effect in Humans

Anne‐Marie Faucher, Murray D. Bailey, Pierre L. Beaulieu, +11

Organic Letters

Medicinal ChemistryNs3 Protease InhibitorMedicineImmunologyAntiviral Drug Development +11

Preclinical Profile of BI 224436, a Novel HIV-1 Non-Catalytic-Site Integrase Inhibitor

Craig Fenwick, Ma’an Amad, Murray D. Bailey, +24

Antimicrobial Agents and Chemotherapy

An NS3 Serine Protease Inhibitor Abrogates Replication of Subgenomic Hepatitis C Virus RNA

Arnim Pause, George Kukolj, Murray D. Bailey, +11

Journal of Biological Chemistry