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Identification of 1-{2-[4-chloro-1′-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4′-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y1 antagonist as an antiplatelet agent

Yoon Jeon, Wu Yang, Jennifer X. Qiao, Ling Li, Réjean Ruel, Carl Thibeault, Sheldon Hiebert, Tammy C. Wang, Yufeng Wang, Yajun Liu,

Bioorganic & Medicinal Chemistry Letters · 2014 · 19 citations · 16 references

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References

16

Dansyl Glutathione as a Trapping Agent for the Quantitative Estimation and Identification of Reactive Metabolites

Jinping Gan, Timothy W. Harper, Mei-Mann Hsueh et al. · Chemical Research in Toxicology · 2005 · 177 citations

, , +16

MRS2500 [2-Iodo-N6-methyl-(N)-methanocarba-2′-deoxyadenosine-3′,5′-bisphosphate], a Potent, Selective, and Stable Antagonist of the Platelet P2Y1 Receptor with Strong Antithrombotic Activity in Mice

Béatrice Hechler, Christelle Nonne, Eun Joo Roh et al. · Journal of Pharmacology and Experimental Therapeutics · 2006 · 149 citations · Full text

, , +17

P2 receptors and platelet function

Béatrice Hechler, Christian Gachet · Purinergic Signalling · 2011 · 133 citations · Full text

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In Vitro Screening of 50 Highly Prescribed Drugs for Thiol Adduct Formation—Comparison of Potential for Drug-Induced Toxicity and Extent of Adduct Formation

Jinping Gan, Qian Ruan, Bing He et al. · Chemical Research in Toxicology · 2009 · 99 citations

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Conformationally Constrained <i>ortho-</i>Anilino Diaryl Ureas: Discovery of 1-(2-(1′-Neopentylspiro[indoline-3,4′-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a Potent, Selective, and Bioavailable P2Y<sub>1</sub> Antagonist

Jennifer X. Qiao, Tammy C. Wang, Réjean Ruel et al. · Journal of Medicinal Chemistry · 2013 · 70 citations · Full text

, , +17