Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy

Andrew K. Dilger, Kumar B. Pabbisetty, James R. Corte, +29

Journal of Medicinal Chemistry

Multiplexed assay panel of cytotoxicity in HK-2 cells for detection of renal proximal tubule injury potential of compounds

Wu Yang, David Connors, Lauren E. Barber, +3

Toxicology in Vitro

UrologyRenal FunctionHk-2 CellsMedicineBioanalysis +12

Efficient Synthesis of 2-Aryl-6-chloronicotinamides via PXPd2-Catalyzed Regioselective Suzuki Coupling

Wu Yang, Yufeng Wang, James R. Corte

Organic Letters

Chemical EngineeringCross-coupling ReactionEngineeringAryl Boronic AcidsShortest Reaction Times +7

Discovery and Structure−Activity Relationships of Trisubstituted Pyrimidines/Pyridines as Novel Calcium-Sensing Receptor Antagonists

Wu Yang, Zheming Ruan, Yufeng Wang, +7

Journal of Medicinal Chemistry

A Novel Calcium-Sensing Receptor Antagonist Transiently Stimulates Parathyroid Hormone Secretion in Vivo

Brian J. Arey, Ramakrishna Seethala, Zhengping Ma, +7

Endocrinology

Parathyroid DiseaseParathyroid GlandOsteoporosisCellular PhysiologyParathyroid Hormone +15

Discovery and structure–activity relationships of 2-benzylpyrrolidine-substituted aryloxypropanols as calcium-sensing receptor antagonists

Wu Yang, Yufeng Wang, Jacques Y. Roberge, +7

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMolecular PharmacologyCalcium-sensing Receptor AntagonistsBiochemistryMedicine +7

A Missense Mutation in the Seven-transmembrane Domain of the Human Ca2+ Receptor Converts a Negative Allosteric Modulator into a Positive Allosteric Modulator

Jianxin Hu, Jian‐kang Jiang, Stefano Costanzi, +5

Journal of Biological Chemistry

Drug TargetMolecular BiologyCellular PhysiologyPositive Allosteric ModulatorNegative Allosteric Modulator +16

Discovery of 4-Aryl-7-Hydroxyindoline-Based P2Y₁ Antagonists as Novel Antiplatelet Agents

Wu Yang, Yufeng Wang, Amy Lai, +14

Journal of Medicinal Chemistry

Adenosine DiphosphatePharmacotherapyPlatelet AggregationPharmaceutical ChemistryMolecular Pharmacology +17

Synthesis and structure–activity relationship of 3-arylbenzoxazines as selective estrogen receptor β agonists

Wu Yang, Yufeng Wang, Zhengping Ma, +8

Bioorganic & Medicinal Chemistry Letters

Structure–activity RelationshipMolecular PharmacologyMedicineHormonal ReceptorMechanism Of Action +4

Discovery of novel 1-arylmethyl pyrrolidin-2-yl ethanol amines as calcium-sensing receptor antagonists

Ashvinikumar V. Gavai, Roy J. Vaz, Amarendra B. Mikkilineni, +10

Bioorganic & Medicinal Chemistry Letters

Calcium-sensing Receptor AntagonistsBiochemistryFunctional SelectivityMedicineReceptor (Biochemistry) +5