Travis Stams

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

Ying-Nan P. Chen, Matthew J. LaMarche, Ho Man Chan et al. · Nature · 2016 · 929 citations

Life Sciences, Cell Biology, Oncology +16

Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor

Jorge Fortanet, Christine Hiu-Tung Chen, Ying-Nan P. Chen et al. · Journal of Medicinal Chemistry · 2016 · 291 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer

Matthew J. LaMarche, Michael Acker, Andreea Argintaru et al. · Journal of Medicinal Chemistry · 2020 · 222 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition

Jonathan R. LaRochelle, Michelle Fodor, Vidyasiri Vemulapalli et al. · Nature Communications · 2018 · 171 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Protein component of the ribozyme ribonuclease P alters substrate recognition by directly contacting precursor tRNA

Travis Stams, Sharon M. Crary, David W. Christianson et al. · Proceedings of the National Academy of Sciences · 1998 · 163 citations

Life Sciences, Biochemistry, Molecular Biology +15