Tamara D. Cabalu

Discovery of the Dual Orexin Receptor Antagonist [(7<i>R</i>)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2<i>H</i>-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia

Christopher D. Cox, Michael J. Breslin, David B. Whitman et al. · Journal of Medicinal Chemistry · 2010 · 367 citations · Full text

Psychotropic Medication, Pharmacotherapy, Primary Insomnia +17

Discovery of [(2<i>R</i>,5<i>R</i>)‐5‐{[(5‐Fluoropyridin‐2‐yl)oxy]methyl}‐2‐methylpiperidin‐1‐yl][5‐methyl‐2‐(pyrimidin‐2‐yl)phenyl]methanone (MK‐6096): A Dual Orexin Receptor Antagonist with Potent Sleep‐Promoting Properties

Paul J. Coleman, John D. Schreier, Christopher D. Cox et al. · ChemMedChem · 2012 · 121 citations

Sleep Disorders, Neurotransmitter, Peptide Science +19

Discovery of 5′′‐Chloro‐<i>N</i>‐[(5,6‐dimethoxypyridin‐2‐yl)methyl]‐2,2′:5′,3′′‐terpyridine‐3′‐carboxamide (MK‐1064): A Selective Orexin 2 Receptor Antagonist (2‐SORA) for the Treatment of Insomnia

Anthony J. Roecker, Swati P. Mercer, John D. Schreier et al. · ChemMedChem · 2013 · 65 citations

Recommendations for the Design of Clinical Drug–Drug Interaction Studies With Itraconazole Using a Mechanistic <scp>Physiologically‐Based Pharmacokinetic</scp> Model

Yuan Chen, Tamara D. Cabalu, Ernesto Callegari et al. · CPT Pharmacometrics & Systems Pharmacology · 2019 · 46 citations · Full text

<i>In vitro</i> and <i>in vivo</i> characterisation of the metabolism and disposition of suvorexant in humans

Donghui Cui, Tamara D. Cabalu, Ka Lai Yee et al. · Xenobiotica · 2016 · 37 citations

Gastrointestinal Pharmacology, Pharmacotherapy, Experimental Pharmacology +19