Anthony J. Roecker

Natural Product-like Combinatorial Libraries Based on Privileged Structures. 1. General Principles and Solid-Phase Synthesis of Benzopyrans

K. C. Nicolaou, Jeffrey A. Pfefferkorn, Anthony J. Roecker et al. · Journal of the American Chemical Society · 2000 · 674 citations

Pharmacy, Chemistry, Medicinal Chemistry +13

A Chemical, Genetic, and Structural Analysis of the Nuclear Bile Acid Receptor FXR

Michael Downes, Mark A. Verdecia, Anthony J. Roecker et al. · Molecular Cell · 2003 · 386 citations · Full text

Life Sciences, Biochemistry, Genetics +13

Discovery of the Dual Orexin Receptor Antagonist [(7<i>R</i>)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2<i>H</i>-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia

Christopher D. Cox, Michael J. Breslin, David B. Whitman et al. · Journal of Medicinal Chemistry · 2010 · 370 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +12

Natural Product-like Combinatorial Libraries Based on Privileged Structures. 2. Construction of a 10 000-Membered Benzopyran Library by Directed Split-and-Pool Chemistry Using NanoKans and Optical Encoding

K. C. Nicolaou, Jeffrey A. Pfefferkorn, Helen J. Mitchell et al. · Journal of the American Chemical Society · 2000 · 270 citations

Pharmacy, Chemical Biology, Chemistry +17

Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors

Jie Yin, Kerim Babaoglu, Chad A. Brautigam et al. · Nature Structural & Molecular Biology · 2016 · 150 citations

Life Sciences, Neuroscience, Pharmacology +10