Brant Firestone

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

Ying-Nan P. Chen, Matthew J. LaMarche, Ho Man Chan et al. · Nature · 2016 · 893 citations

Cancer Research, Allosteric Inhibition, Signal Transduction +12

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

Elizabeth C. Townsend, Mark A. Murakami, Alexandra Christodoulou et al. · Cancer Cell · 2016 · 302 citations · Full text

Knockout Mouse, Xenotransplantation, Xenografts Enables Discovery +9

Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor

Jorge Fortanet, Christine Hiu-Tung Chen, Ying-Nan P. Chen et al. · Journal of Medicinal Chemistry · 2016 · 284 citations · Full text

Allosteric Inhibition, Drug Target, Shp2 Inhibition +20

Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer

Matthew J. LaMarche, Michael Acker, Andreea Argintaru et al. · Journal of Medicinal Chemistry · 2020 · 207 citations · Full text

IAP inhibitors enhance co-stimulation to promote tumor immunity

Michael Dougan, Stephanie K. Dougan, Joanna Slisz et al. · The Journal of Experimental Medicine · 2010 · 146 citations · Full text

Iap Antagonism, Immunology, Immune Regulation +27