Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

Ying-Nan P. Chen, Matthew J. LaMarche, Ho Man Chan, +50

Nature

Cancer ResearchAllosteric InhibitionSignal TransductionSignaling PathwayMedicine +10

A Smac Mimetic Rescue Screen Reveals Roles for Inhibitor of Apoptosis Proteins in Tumor Necrosis Factor-α Signaling

Alex Gaither, Dale Porter, Yao Yao, +16

Cancer Research

ApoptosisImmunologyCell DeathPathologyImmunotherapy +17

Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer

Matthew J. LaMarche, Michael Acker, Andreea Argintaru, +61

Journal of Medicinal Chemistry

IAP inhibitors enhance co-stimulation to promote tumor immunity

Michael Dougan, Stephanie K. Dougan, Joanna Slisz, +11

The Journal of Experimental Medicine

Iap AntagonismImmunologyImmune RegulationCell DeathImmunoediting +25

TRANSPLANTATION TOLERANCE PREVENTS CARDIAC ALLOGRAFT VASCULOPATHY IN MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I-DISPARATE MINIATURE SWINE1

Joren C. Madsen, Kazuhiko Yamada, James S. Allan, +6

Transplantation

Widespread haploid-biased gene expression enables sperm-level natural selection

Kunal Bhutani, Katherine Stansifer, Simina Ticau, +8

Science

THE EFFECT OF THYMECTOMY ON TOLERANCE INDUCTION AND CARDIAC ALLOGRAFT VASCULOPATHY IN A MINIATURE SWINE HEART/KIDNEY TRANSPLANTATION MODEL1,2

Kazuhiko Yamada, Joseph Choo, James S. Allan, +8

Transplantation

Mechanisms of tolerance induction and prevention of cardiac allograft vasculopathy in miniature swine: The effect of augmentation of donor antigen load

Kazuhiko Yamada, Kwabena Mawulawde, Matthew T. Menard, +7

Journal of Thoracic and Cardiovascular Surgery

TransplantationXenotransplantationDonor Antigen LoadPhysiologyImmunology +9

CREATION OF THE "THYMOHEART" ALLOGRAFT

Denis Lambrigts, Matthew T. Menard, Guy P. Alexandre, +13

Transplantation

Morphometric analysis of miniature swine hearts as potential human xenografts

James S. Allan, Geoff A. Rose, Joseph Choo, +6

Xenotransplantation

Cardiac MuscleHeart FailureAnatomyBiomedical EngineeringMitral Valve Annulus +19