Sonnet S. Davis

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

Christopher D. Wiley, Michael C. Velarde, Pacôme Lecot et al. · Cell Metabolism · 2015 · 1.1K citations · Full text

Aging, Mitochondrial Function, Longevity +6

TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge

Alicia Nugent, Karin Lin, Bettina van Lengerich et al. · Neuron · 2020 · 697 citations · Full text

Inflammation, Immunology, Chronic Inflammation +7

Alzheimer’s-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia

Benjamin J. Andreone, Laralynne Przybyla, Ceyda Llapashtica et al. · Nature Neuroscience · 2020 · 235 citations

Inflammation, Trem2 Function, Neurodegenerative Diseases +14

Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson’s disease

Danna Jennings, Sarah Huntwork‐Rodriguez, Anastasia G. Henry et al. · Science Translational Medicine · 2022 · 230 citations

A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models

Bettina van Lengerich, Lihong Zhan, Dan Xia et al. · Nature Neuroscience · 2023 · 213 citations · Full text