Laralynne Przybyla

TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge

Alicia Nugent, Karin Lin, Bettina van Lengerich et al. · Neuron · 2020 · 697 citations · Full text

Inflammation, Immunology, Chronic Inflammation +7

Alzheimer’s-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia

Benjamin J. Andreone, Laralynne Przybyla, Ceyda Llapashtica et al. · Nature Neuroscience · 2020 · 235 citations

Inflammation, Trem2 Function, Neurodegenerative Diseases +14

Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic

Todd Logan, Matthew Simon, Gerald Maxwell Cherf et al. · Cell · 2021 · 210 citations · Full text

Neurodegenerative Diseases, Molecular Neuroscience, Lysosomal Storage Disorder +11

Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation

Laralynne Przybyla, Johnathon N. Lakins, Valerie M. Weaver · Cell stem cell · 2016 · 180 citations

Developmental Biology, Cell Specialization, Medicine +7

A tension-mediated glycocalyx–integrin feedback loop promotes mesenchymal-like glioblastoma

J. Matthew Barnes, Shelly Kaushik, Russell Bainer et al. · Nature Cell Biology · 2018 · 170 citations · Full text

Neuro-oncology, Glioma, Mesenchymal-like Glioblastoma +5