Arnold P. den Hartog

Synthesis, Biological Properties, and Molecular Modeling Investigations of Novel 3,4-Diarylpyrazolines as Potent and Selective CB₁ Cannabinoid Receptor Antagonists

Jos H.M. Lange, Hein K. A. C. Coolen, Herman H. van Stuivenberg et al. · Journal of Medicinal Chemistry · 2003 · 186 citations · Full text

Drug Target, Biological Properties, X-ray Diffraction Study +21

Design, Synthesis and Biological Activity of Rigid Cannabinoid CB1 Receptor Antagonists.

Axel R. Stoit, Jos H.M. Lange, Arnold P. den Hartog et al. · Chemical and Pharmaceutical Bulletin · 2002 · 61 citations · Full text

Pyrazole Ring Closure, Pharmacotherapy, Heterocycle Chemistry +19

Synthesis, Structure−Activity Relationships, and Biological Properties of 1-Heteroaryl-4-[ω-(1<i>H</i>-indol-3-yl)alkyl]piperazines, Novel Potential Antipsychotics Combining Potent Dopamine D₂ Receptor Antagonism with Potent Serotonin Reuptake Inhibition

Pieter Smid, Hein K. A. C. Coolen, Hiskias G. Keizer et al. · Journal of Medicinal Chemistry · 2005 · 58 citations · Full text

Psychopharmacology, Biological Properties, Pharmacotherapy +18

Synthesis and SAR of 1,4,5,6-tetrahydropyridazines as potent cannabinoid CB1 receptor antagonists

Jos H.M. Lange, Arnold P. den Hartog, Martina A.W. van der Neut et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 48 citations · Full text

Cannabis Use, Functional Selectivity, Medicine +4

Synthesis and SAR of novel imidazoles as potent and selective cannabinoid CB2 receptor antagonists with high binding efficiencies

Jos H.M. Lange, Martina A.W. van der Neut, Henri C. Wals et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 27 citations · Full text

Cannabis Use, Medicinal Chemistry, Drug Target +11